PDF) A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors
Frontiers | Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies
IJMS | Free Full-Text | Molecular Mechanisms of Drug Resistance in Glioblastoma | HTML
Patient-Specific Orthotopic Glioblastoma Xenograft Models Recapitulate the Histopathology and Biology of Human Glioblastomas In Situ - ScienceDirect
Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development | Molecular Cancer | Full Text
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma | Nature Communications
Development of a novel preclinical glioblastoma mouse model and therapeutic impact of IRE1 inhibition | bioRxiv
Orthotopic GBM model characterization. (A) Tumor cells were isolated... | Download Scientific Diagram
Buparlisib is a brain penetrable pan-PI3K inhibitor | Scientific Reports
Small Molecule Inhibitors in Adult High-Grade Glioma: From the Past to the Future - Frontiers
Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug Response | bioRxiv
Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases | Nature Medicine
Cells | Free Full-Text | PI3K/AKT/mTOR-Targeted Therapy for Breast Cancer | HTML
IJMS | Free Full-Text | Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma | HTML
PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation - ScienceDirect
Frontiers | Small Molecule Inhibitors in Adult High-Grade Glioma: From the Past to the Future
AZD9291 inhibits GBM tumorigenesis in vivo. a Mice bearing U87... | Download Scientific Diagram
Frontiers | Next-Generation in vivo Modeling of Human Cancers
PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathway genes are over-expressed in... | Download Scientific Diagram
A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity - ScienceDirect
A) Schematic of procedure for generating orthotopic glioblastoma mouse... | Download Scientific Diagram
Novel Therapeutic Venues for Glioblastoma: Novel Rising Preclinical Treatment Opportunities | IntechOpen
